Opportunity Information: Apply for CDC RFA GH21 2160
The Centers for Disease Control and Prevention (CDC), under the U.S. Department of Health and Human Services, announced a discretionary funding opportunity (CDC RFA GH21 2160) to support hospital-based birth defects surveillance in Kampala, Uganda as part of the President's Emergency Plan for AIDS Relief (PEPFAR). The award mechanism is a cooperative agreement, which typically means the recipient would carry out the day-to-day work while CDC remains substantially involved through technical guidance, collaboration on implementation, and ongoing oversight of key program elements.
The main purpose of the grant is twofold. First, it is designed to continue an existing birth defects surveillance system across at least four major hospitals in Kampala, with a specific focus on identifying and documenting major external structural birth defects in newborns. This type of surveillance generally involves standardized case finding at delivery sites, consistent clinical definitions, training for clinicians and surveillance staff, structured data collection, and routine quality checks so that the resulting estimates are credible and comparable over time. By concentrating on major external structural defects, the system prioritizes conditions that can be recognized through physical examination at birth, which helps ensure more reliable detection in busy hospital settings and supports trend monitoring.
Second, the opportunity is intended to evaluate whether taking certain medications very early in pregnancy is linked to a higher risk of birth defects. The NOFO specifically highlights dolutegravir (an antiretroviral commonly used in HIV treatment), cotrimoxazole (often used for prophylaxis against opportunistic infections), and potentially other medications used around the time of conception and early gestation. Because many structural birth defects develop in the earliest weeks of pregnancy, the grant emphasizes exposure during very early pregnancy, when medication-related risks, if they exist, are most likely to affect fetal development. In practical terms, this objective requires careful collection of maternal medication histories, clear timing of exposure relative to pregnancy, and linkage of those exposures to birth outcomes captured by the hospital surveillance platform.
The expected public health value of the work is to produce three core outputs that can inform policy and clinical practice. The first is reliable background rates of major external structural birth defects in Kampala, which are essential for understanding what is typical in the local context and for detecting any changes over time. The second is baseline information on how frequently pregnant people are using HIV-related and other relevant medications, which helps quantify real-world exposure patterns rather than relying only on program guidelines. The third is an assessment of whether there is any observable association between early pregnancy medication exposure and external structural birth defects, offering evidence that can either reassure programs about medication safety or signal the need for closer review, updated counseling, or alternative regimens.
Funding details in the announcement note that the Year 1 award ceiling is listed as 0 (none), while CDC anticipated an approximate total fiscal year funding amount of 1,000,000 for Year 1, contingent on funds being available. Only one award was expected. The opportunity was posted March 4, 2021, with an original closing date of May 4, 2021, and applications were required to be submitted electronically by 11:59 p.m. Eastern Time on the due date. Eligibility is described broadly as "Others" with further clarification referenced in the full eligibility text of the announcement.
Overall, this grant opportunity centers on strengthening and maintaining a hospital-based surveillance system capable of producing timely, high-quality birth outcomes data in Kampala, and then using that platform to answer a high-priority medication safety question relevant to HIV treatment in pregnancy. The NOFO explicitly states that the World Health Organization (WHO) and PEPFAR plan to use findings from this work to inform guidance on the use of specific HIV medications during pregnancy, making the surveillance results directly relevant to clinical recommendations and program policy in settings where these medicines are widely used.Apply for CDC RFA GH21 2160
- The Department of Health and Human Services, Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "Hospital Based Birth Defects Surveillance in Kampala, Uganda under the President's Emergency Plan for AIDS Relief (PEPFAR)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067.
- This funding opportunity was created on Mar 04, 2021.
- Applicants must submit their applications by May 04, 2021 Electronically submitted applications must be submitted no later than 1159 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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