Opportunity Information: Apply for CDC RFA GH21 2123

This funding opportunity (CDC RFA GH21-2123) is a PEPFAR-supported cooperative agreement from the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), focused on strengthening South Africa's health information systems (HIS) through hands-on technical assistance. The overall intent is to help the South African National Department of Health (NDoH) and sub-national health authorities improve patient-level data systems by building and refining digital health platforms that can connect to each other and work as an integrated ecosystem. The emphasis is on making existing and future systems more useful for frontline care, program management, and decision-making by improving interoperability, data quality, and practical use of information across the health sector.

The core technical scope centers on developing and implementing digital platforms that allow different national and sub-national systems to exchange data reliably. The opportunity specifically highlights interoperability across clinical information systems, laboratory systems, demographic and patient registry-type capabilities (including HPRS), program monitoring platforms (including WebDHIS), differentiated service delivery systems, mHealth tools, and other related systems and subsystems. In plain terms, the work is meant to reduce fragmentation so that patient information and program data can be linked and used across services and levels of care, rather than sitting in disconnected databases that do not communicate. By improving how these systems connect, the CDC expects stronger continuity of care, better monitoring of patient outcomes, and more accurate reporting and planning at facility, district, provincial, and national levels.

Recipients are expected to operate in close partnership with the South African government rather than working independently. A key requirement is alignment with NDoH policies and national digital health strategy objectives, with active coordination among the NDoH, Provincial Departments of Health (PDoH), and other health information system stakeholders and district support partners (DSPs). The award focuses on organizing, supporting, and accelerating the development, implementation, and scale-up of HIS integration efforts across South Africa, including improving existing systems so that integrated data can actually be used for patient-centered service delivery and for management decisions. Sustainability is explicitly called out, meaning the technical assistance should help government institutions adopt approaches that can be maintained long term at all levels of the health system, rather than creating solutions that depend permanently on external implementers.

A major expected outcome area is improved data quality and stronger data use. The technical assistance is intended to make patient-level information more reliable and actionable, which supports higher-quality, patient-centered healthcare services and enables better planning and resource allocation. This includes supporting the ability of the HIS to generate usable insights for program improvement, routine management, and strategic decisions, reflecting a shift from data collected mainly for reporting to data actively used to guide services and policy.

The opportunity also expects ongoing monitoring of progress through process and outcome evaluation checks. In practice, this means recipients should establish ways to track whether the technical support is actually leading to measurable improvements in system integration, usability, and performance against the NOFO's expected outcomes, and then use those findings to adjust implementation.

From a funding and administrative standpoint, the award instrument is a cooperative agreement, which typically implies substantial involvement and collaboration with CDC during implementation. The funding activity category is Health, and the CFDA/Assistance Listing number is 93.067. Eligibility is listed as unrestricted (open to any type of entity, subject to any additional eligibility clarifications in the full notice). CDC anticipated making two awards. For budgeting, the notice states that the Year 1 award ceiling is listed as 0 (none), while CDC anticipated an approximate total fiscal year funding amount of $5,000,000 for Year 1, contingent on funds being available. The opportunity was created March 3, 2021, with an original closing date of May 2, 2021, and required electronic submission by 11:59 pm ET on the due date.

Overall, this NOFO is essentially a targeted investment in the technical capacity, governance alignment, and practical implementation support needed for South Africa to run more integrated, interoperable, and sustainable health information systems that strengthen patient-level data and improve how data is used to deliver and manage health services under PEPFAR-supported objectives.

  • The Department of Health and Human Services, Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "Technical Assistance (TA) to Support the Health Information Systems (HIS) of the South African Government to Improve Patient-level Data Systems at the National and Sub-National Departments of Health (DoH) under PEPFAR" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067.
  • This funding opportunity was created on Mar 03, 2021.
  • Applicants must submit their applications by May 02, 2021 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The number of recipients for this funding is limited to 2 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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