Opportunity Information: Apply for PA 19 121
The NIH Midcareer Investigator Award in Patient-Oriented Research (K24) is a career development grant aimed at established, mid-career clinician-researchers who already have a track record in patient-oriented research and are positioned to both deepen their own research programs and train the next generation of clinical investigators. The core idea is to buy protected time for a health-professional doctorate to focus on patient-oriented research (POR) while also formalizing and strengthening their role as a research mentor. Mentorship is not a side feature here; the award is structured so that recipients spend significant effort mentoring primarily clinical residents, clinical fellows, and/or junior clinical faculty, helping them develop into independent patient-oriented researchers.
This particular Funding Opportunity Announcement, PA 19-121, is the K24 "Independent Clinical Trial Required" version. That means applicants must be proposing to lead an independent clinical trial as part of their research and career development plan. NIH includes several qualifying scenarios under that umbrella: serving as lead investigator of a full independent clinical trial, conducting a clinical trial feasibility study, or leading a separate ancillary clinical trial that is distinct and scientifically justified. The point is that the applicant is not simply participating in someone else’s trial to gain experience; they are expected to be in charge of the trial (or the feasibility/ancillary trial) and responsible for its scientific leadership. If an applicant is not planning to lead an independent clinical trial, or instead plans to obtain clinical trial experience under another investigator’s trial, NIH directs them to apply to the companion FOA (PA-18-394) rather than this one.
Administratively, this is a discretionary grant funded by the National Institutes of Health under an activity category associated with education and health, reflecting the blend of mentored career development and research leadership. The opportunity lists multiple CFDA numbers (now part of Assistance Listings), indicating that different NIH Institutes and Centers may use this mechanism to support K24 awards across a range of disease areas and clinical research topics. While the listing provides an "OriginalClosingDate" of 2020-05-07 and does not specify an award ceiling or expected number of awards in the provided text, the defining features remain the purpose of protecting the investigator’s time, advancing patient-oriented research, and building mentorship capacity within clinical training environments.
Eligibility is broad at the organizational level and includes many common U.S. applicant organization types: public and private institutions of higher education; state, county, and city or township governments; special district governments; independent school districts; federally recognized Native American tribal governments; public housing authorities/Indian housing authorities; nonprofit organizations (both 501(c)(3) and non-501(c)(3), other than higher education institutions); for-profit organizations (other than small businesses) as well as small businesses; and an "other" category that typically captures additional eligible entities defined by NIH policy. The FOA also explicitly highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, eligible federal agencies, and Indian/Native American tribal governments other than federally recognized tribes. At the same time, it draws clear boundaries around foreign participation: non-domestic (non-U.S.) entities and non-domestic components of U.S. organizations are not eligible to apply as the applicant organization. However, foreign components as defined in the NIH Grants Policy Statement are allowed, meaning a U.S.-based applicant organization may include certain international elements in the project when justified and compliant with NIH policy.
In practical terms, the K24 is best understood as an investment in a mid-career clinician-investigator who can demonstrate three things at once: a strong and ongoing patient-oriented research program, a credible plan to lead an independent clinical trial (or feasibility/ancillary clinical trial) under this FOA, and a robust mentoring plan that will translate the award’s protected time into measurable training and career advancement outcomes for mentees in clinical research pathways. The emphasis on patient-oriented research and hands-on mentoring reflects NIH’s goal of strengthening the clinical research workforce by supporting experienced investigators who can simultaneously produce high-quality human-subjects research and build durable mentorship pipelines within academic medical centers and other clinical research settings.Apply for PA 19 121
- The National Institutes of Health in the education, environment, health sector is offering a public funding opportunity titled "Midcareer Investigator Award in Patient-Oriented Research (Parent K24 Independent Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.173, 93.213, 93.233, 93.242, 93.273, 93.279, 93.361, 93.837, 93.838, 93.839, 93.840, 93.846, 93.855, 93.866.
- This funding opportunity was created on 2018-12-20.
- Applicants must submit their applications by 2020-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 19 121) also looked into and applied for these:
| Funding Opportunity |
|---|
| Midcareer Investigator Award in Patient-Oriented Research (Parent K24 Independent Clinical Trial Not Allowed) Apply for PA 19 122 Funding Number: PA 19 122 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Independent Scientist Award (Parent K02 - Independent Clinical Trial Required) Apply for PA 19 131 Funding Number: PA 19 131 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Independent Scientist Award (Parent K02 - Independent Clinical Trial Not Allowed) Apply for PA 19 132 Funding Number: PA 19 132 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| U.S.-China Program for Biomedical Collaborative Research (R01 Clinical Trial Optional) Apply for RFA CA 19 009 Funding Number: RFA CA 19 009 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $150,000 |
| Bioengineering Research Grants (BRG) (R01 Clinical Trial Not Allowed) Apply for PAR 19 158 Funding Number: PAR 19 158 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Summer Research Education Experience Program (Clinical Trials Not Allowed R25) Apply for PAR 19 164 Funding Number: PAR 19 164 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $100,000 |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Senior Fellowship (Parent F33) Apply for PA 19 187 Funding Number: PA 19 187 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Summer Research Education Experience Program (R25 Clinical Trial Not Allowed) Apply for PAR 19 197 Funding Number: PAR 19 197 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $100,000 |
| Building Interdisciplinary Research Careers in Women's Health (BIRCWH); K12 Clinical Trial Optional Apply for RFA OD 19 020 Funding Number: RFA OD 19 020 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $600,000 |
| Basic and Translational Research on Adducts in Cancer Risk Identification and Prevention (R21 Clinical Trial Optional) Apply for PAR 19 252 Funding Number: PAR 19 252 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| Environmental Influences on Aging: Effects of Extreme Weather and Disaster Events on Aging Populations (R01 Clinical Trial Optional) Apply for PAR 19 250 Funding Number: PAR 19 250 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Basic and Translational Research on Adducts in Cancer Risk Identification and Prevention (R01 Clinical Trial Optional) Apply for PAR 19 251 Funding Number: PAR 19 251 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Dissemination and Implementation Research in Health (R21 Clinical Trial Optional) Apply for PAR 19 275 Funding Number: PAR 19 275 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| Mechanism for Time-Sensitive Research Opportunities in Environmental Health Sciences (R21 Clinical Trial Not Allowed) Apply for RFA ES 19 011 Funding Number: RFA ES 19 011 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| The Intersection of Sex and Gender Influences on Health and Disease (R01 Clinical Trial Optional) Apply for RFA OD 19 029 Funding Number: RFA OD 19 029 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Development of Highly Innovative Tools and Technology for Analysis of Single Cells (SBIR) (R43/R44 Clinical Trial Not Allowed) Apply for PA 20 047 Funding Number: PA 20 047 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Development of Highly Innovative Tools and Technology for Analysis of Single Cells (STTR) (R41/R42 Clinical Trial Not Allowed) Apply for PA 20 025 Funding Number: PA 20 025 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Biomedical Data Repository (U24 - Clinical Trials Not Allowed) Apply for PAR 20 089 Funding Number: PAR 20 089 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Biomedical Knowledgebase (U24 - Clinical Trials Not Allowed) Apply for PAR 20 097 Funding Number: PAR 20 097 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (R01 Clinical Trials Not Allowed) Apply for PAR 20 165 Funding Number: PAR 20 165 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
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