Opportunity Information: Apply for PAR 22 044

The NIDCR Dentist Scientist Career Transition Award for Intramural Investigators (K22 Clinical Trial Not Allowed) is an NIH grant program designed to help highly qualified dentist-scientists move from the NIH Intramural Research Program into independent, tenure-track or equivalent research positions at extramural institutions. Its core goal is to create a clear, supported pathway from mentored postdoctoral training inside NIH to running an independent research program outside NIH, with funding that helps launch the awardee as a new investigator. In practical terms, it is meant for dentists currently in NIH intramural postdoctoral fellowship roles who are ready to compete for faculty-level positions and need structured support to establish independence and secure early research momentum.

This opportunity is offered by the National Institutes of Health (NIH) through the National Institute of Dental and Craniofacial Research (NIDCR). It is a discretionary grant program in the health area (CFDA 93.121) and is listed under Funding Opportunity Number PAR-22-044. The "Clinical Trial Not Allowed" designation means applicants must propose research that does not include an NIH-defined clinical trial; projects should stay within basic, translational, mechanistic, or other non-clinical-trial research approaches aligned with NIDCRs mission in dental, oral, and craniofacial science.

A notable feature of the announcement is the broad range of eligible applicant organizations for the extramural phase. Eligible applicants include many types of U.S.-based organizations and government entities, such as public and private institutions of higher education, state and local governments (including county and city/township governments), special district governments, independent school districts, federally recognized Native American tribal governments, and public housing authorities/Indian housing authorities. It also allows nonprofit organizations (both 501(c)(3) and non-501(c)(3), as long as they are not institutions of higher education when categorized that way), for-profit organizations (other than small businesses), small businesses, and other types of organizations that meet NIH eligibility rules. The announcement explicitly highlights additional categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs). It also notes that eligible agencies of the federal government, faith-based or community-based organizations, regional organizations, tribal governments that are not federally recognized, and U.S. territories or possessions may be among the eligible applicants.

At the same time, there are clear limits related to foreign participation. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply, and non-domestic components of U.S. organizations are not eligible to apply. However, foreign components are allowed, as defined in the NIH Grants Policy Statement. That typically means the main applicant organization must be eligible and based in the U.S., but certain elements of the research can involve foreign collaboration or activities if they meet NIH policy requirements and are justified scientifically.

Key administrative details included in the listing are the original closing date of January 7, 2025, and the creation date of January 10, 2022. The listing does not provide an award ceiling or expected number of awards in the provided text, which usually means applicants need to consult the full FOA and NIH budget guidance to understand typical K22 support levels and any institute-specific budget limits.

Overall, the program is best understood as a career transition mechanism: it targets dentist-scientists who have developed strong research capabilities within NIHs intramural environment and are ready to take the next step into independent extramural research careers. It supports that jump by providing a structured, NIH-recognized pathway to independence, while keeping the research scope within non-clinical-trial boundaries and allowing a wide set of U.S. organizations to serve as the extramural home for the emerging investigator.

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIDCR Dentist Scientist Career Transition Award for Intramural Investigators (K22 Clinical Trial Not Allowed)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121.
  • This funding opportunity was created on 2022-01-10.
  • Applicants must submit their applications by 2025-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
Apply for PAR 22 044

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FAQs: NIDCR Dentist Scientist Career Transition Award for Intramural Investigators (K22, Clinical Trial Not Allowed) - PAR-22-044

What is the NIDCR Dentist Scientist Career Transition Award (K22) for Intramural Investigators?

This NIH/NIDCR K22 program is a career transition award designed to help highly qualified dentist-scientists move from the NIH Intramural Research Program into independent, tenure-track (or equivalent) research positions at extramural institutions. The award is intended to provide a clear, supported pathway from mentored postdoctoral training at NIH to launching an independent research program outside NIH.

What is the main purpose of this K22 program?

The core goal is to support the transition from an NIH intramural postdoctoral environment to an independent extramural research career. In practical terms, it helps dentist-scientists who are ready to compete for faculty-level positions establish early research momentum as new investigators at an eligible U.S. institution.

Who is the funding agency and institute behind this opportunity?

The program is offered by the National Institutes of Health (NIH) through the National Institute of Dental and Craniofacial Research (NIDCR).

What is the Funding Opportunity Number (FOA) for this announcement?

The Funding Opportunity Number is PAR-22-044.

What CFDA number and program area does this opportunity fall under?

This is a discretionary grant program in the health area with CFDA 93.121.

What does "Clinical Trial Not Allowed" mean for this K22?

"Clinical Trial Not Allowed" means the proposed research must not include an NIH-defined clinical trial. Research approaches should remain within non-clinical-trial boundaries, such as basic, translational, mechanistic, or other non-clinical-trial research aligned with NIDCR's mission in dental, oral, and craniofacial science.

What kind of applicant is this K22 intended for?

It is meant for dentist-scientists currently in NIH intramural postdoctoral fellowship roles who have strong research capabilities and are ready to transition into independent, tenure-track or equivalent extramural research positions.

Is this program specifically for people leaving the NIH Intramural Research Program?

Yes. This K22 is structured as a transition mechanism from mentored postdoctoral training inside the NIH Intramural Research Program to an independent extramural position.

What types of organizations can serve as the extramural institution for the award?

The announcement describes a broad range of eligible U.S.-based applicant organizations and government entities for the extramural phase, including public and private institutions of higher education and multiple types of government and organizational settings, as long as they meet NIH eligibility rules.

Are institutions of higher education eligible?

Yes. Eligible applicants include both public and private institutions of higher education.

Are state and local government entities eligible to apply?

Yes. The announcement includes state governments and local governments, including county governments and city or township governments.

Are special district governments and independent school districts eligible?

Yes. Special district governments and independent school districts are included among eligible applicants.

Are tribal governments eligible?

Federally recognized Native American tribal governments are included as eligible applicants. The announcement also notes that tribal governments that are not federally recognized may be among the eligible applicants.

Are public housing authorities or Indian housing authorities eligible?

Yes. Public housing authorities and Indian housing authorities are included as eligible applicants.

Can nonprofit organizations apply?

Yes. The announcement allows nonprofit organizations, including both 501(c)(3) and non-501(c)(3) nonprofits, as long as they are not categorized as institutions of higher education when applying in that capacity.

Can for-profit organizations apply?

Yes. For-profit organizations (other than small businesses) are included among eligible applicants, and small businesses are also listed separately as eligible.

Are small businesses eligible under this opportunity?

Yes. Small businesses are included among eligible applicant organizations.

Does the announcement encourage or include specific types of minority-serving institutions?

Yes. The announcement explicitly highlights eligibility that includes Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs).

Are faith-based or community-based organizations eligible?

Yes. The announcement notes that faith-based or community-based organizations may be among eligible applicants.

Are regional organizations eligible to apply?

Yes. Regional organizations are mentioned as potentially eligible applicants.

Are U.S. federal government agencies eligible to apply?

Yes. The announcement notes that eligible agencies of the federal government may be among the eligible applicants.

Are U.S. territories or possessions eligible?

Yes. The announcement notes that U.S. territories or possessions may be among the eligible applicants.

Are foreign (non-U.S.) organizations eligible to apply?

No. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply under this opportunity.

Can a U.S. organization apply if the project includes a non-domestic component?

No. Non-domestic components of U.S. organizations are not eligible to apply.

Are foreign components allowed at all?

Yes. Foreign components are allowed as defined in the NIH Grants Policy Statement. This generally means the main applicant organization must be eligible and U.S.-based, but certain elements of the research may involve foreign collaboration or activities if they meet NIH policy requirements and are scientifically justified.

What is the closing date listed for this opportunity?

The listing includes an original closing date of January 7, 2025.

What is the creation date of the opportunity listing?

The listing shows a creation date of January 10, 2022.

Does the provided listing include an award ceiling or the expected number of awards?

No. The provided text does not include an award ceiling or an expected number of awards. Applicants typically need to consult the full FOA and NIH budget guidance for typical K22 support levels and any institute-specific budget limits.

How should applicants think about the research scope for this award?

Based on the provided description, the research should align with NIDCR's mission in dental, oral, and craniofacial science and must stay within non-clinical-trial approaches (for example, basic, translational, or mechanistic work that is not an NIH-defined clinical trial).

What stage of career does this award support?

This program targets dentist-scientists who have completed substantial mentored training within the NIH intramural environment and are prepared to move into independent extramural research careers as new investigators.

What is the practical benefit of this program for a transitioning investigator?

The program is designed to provide structured support recognized by NIH to help an intramural postdoctoral dentist-scientist transition into a faculty-level independent research role at an eligible extramural institution, with funding intended to help launch and stabilize an early independent research program.

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