Opportunity Information: Apply for RFA DK 17 511
This funding opportunity, RFA-DK-17-511, is a limited-competition cooperative agreement (U01; clinical trial not allowed) issued by the National Institutes of Health to support the continuation of the Clinical Centers for The Environmental Determinants of Diabetes in the Young (TEDDY) Study. TEDDY is a long-running, large-scale epidemiological research effort focused on understanding the causes of type 1 diabetes (T1D), particularly how environmental exposures may contribute to the development of T1D and the autoimmune processes that precede it. The central purpose of this FOA is to keep the existing TEDDY clinical infrastructure operating so the study can maintain participant engagement, complete ongoing follow-up, and continue collecting high-quality clinical information and biological specimens.
The competition is restricted to the Program Directors/Principal Investigators of the six current TEDDY Clinical Centers. These centers are not newcomers to the project; they helped shape the study and have been responsible for recruiting participants and carrying out protocol-driven follow-up for roughly 15 years. Because TEDDY’s scientific value depends heavily on long-term observation, consistent data capture, and standardized biosample collection across time, the FOA emphasizes continuity. The existing Clinical Centers already have established workflows, trained staff, and operational collaborations with the other TEDDY components, which are critical for keeping the cohort intact and ensuring that measurements remain comparable over time.
From a programmatic standpoint, the supported activities revolve around retaining enrolled TEDDY participants, conducting ongoing clinical follow-up, and continuing the systematic collection of data and biospecimens. These resources are used to investigate potential environmental determinants of T1D, including (as examples highlighted in the description) infectious agents, dietary factors, and other environmental exposures that might be associated with the onset of T1D or the appearance of T1D-related autoimmune markers. In practice, that means the Clinical Centers function as the front line for participant contact and study visits, and they serve as the pipeline for consistently collected samples and well-annotated data that can be analyzed across the consortium.
Mechanistically, this is a discretionary NIH award using a cooperative agreement, which typically indicates substantial NIH program involvement in coordination, oversight, and collaboration to meet shared consortium goals. The FOA falls under health-related activity categories (including food and nutrition and health) and is associated with CFDA numbers 93.847 and 93.855. The listing also notes eligibility that includes public and state-controlled institutions of higher education, while also pointing applicants back to the full announcement for the complete eligibility details given the limited-competition nature of the solicitation.
Key administrative details provided include an original closing date of April 26, 2018, and an award ceiling of $1,100,000. While the source text lists “ExpectedAwards:” without a number, the intent is clearly to fund continuation work at the existing six Clinical Centers rather than to expand the network. Overall, the opportunity is designed to protect the scientific integrity and long-term value of the TEDDY cohort by ensuring the participating sites can keep following subjects and gathering the clinical and biological evidence needed to link specific environmental exposures with T1D development and autoimmunity.Apply for RFA DK 17 511
- The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Limited Competition for the Continuation of the Clinical Centers for The Environmental Determinants of Diabetes in the Young (TEDDY) Study (U01 Clinical Trial Not Allowed )" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847, 93.855.
- This funding opportunity was created on 2018-02-08.
- Applicants must submit their applications by 2018-04-26. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,100,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education.
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FAQs: RFA-DK-17-511 (TEDDY Clinical Centers Continuation)
What is the funding opportunity RFA-DK-17-511?
RFA-DK-17-511 is a limited-competition NIH funding opportunity that uses a cooperative agreement mechanism (U01; clinical trial not allowed) to support the continuation of the Clinical Centers for The Environmental Determinants of Diabetes in the Young (TEDDY) Study.
What is the main purpose of this FOA?
The central purpose is to keep the existing TEDDY clinical infrastructure operating so the study can maintain participant engagement, complete ongoing follow-up, and continue collecting high-quality clinical information and biological specimens over time.
What is the TEDDY Study?
TEDDY is a long-running, large-scale epidemiological research effort focused on understanding the causes of type 1 diabetes (T1D), with particular emphasis on how environmental exposures may contribute to the development of T1D and the autoimmune processes that precede it.
Why does the FOA emphasize continuity of the existing Clinical Centers?
TEDDY's scientific value depends on long-term observation, consistent data capture, and standardized biosample collection across time. The existing Clinical Centers already have established workflows, trained staff, and long-standing operational collaborations across the consortium, which helps preserve comparability of measurements and maintain the cohort.
Who is eligible to apply?
Competition is restricted to the Program Directors/Principal Investigators of the six current TEDDY Clinical Centers. The listing also mentions eligibility categories such as public and state-controlled institutions of higher education, but the solicitation is limited-competition and points applicants to the full announcement for complete eligibility details.
Is this opportunity open to new institutions or new clinical sites?
No. Based on the limited-competition restriction, the opportunity is intended for the existing six TEDDY Clinical Centers rather than adding new sites to the network.
What NIH award mechanism is used?
The award mechanism is a cooperative agreement (U01). This generally indicates substantial NIH program involvement in coordination, oversight, and collaboration to meet shared consortium goals.
Are clinical trials allowed under this FOA?
No. The opportunity is explicitly described as U01 with "clinical trial not allowed."
What kinds of activities would the funded Clinical Centers carry out?
Supported activities revolve around retaining enrolled TEDDY participants, conducting ongoing clinical follow-up, and continuing systematic collection of data and biospecimens. The Clinical Centers serve as the front line for participant contact and study visits and as the pipeline for consistently collected samples and well-annotated data used across the consortium.
What types of scientific questions does TEDDY address?
TEDDY investigates potential environmental determinants of T1D and T1D-related autoimmunity. Examples highlighted include infectious agents, dietary factors, and other environmental exposures that may be associated with the onset of T1D or the appearance of autoimmune markers related to T1D.
Why are biospecimens and standardized data collection so important for this project?
The FOA stresses that TEDDY depends on consistent, standardized collection over time so that data and specimens remain comparable across years and across sites. This helps protect the integrity and long-term value of the cohort for consortium-wide analyses linking exposures to T1D development and autoimmunity.
What is the role of NIH in a cooperative agreement for this project?
Because this is a cooperative agreement, NIH program staff are typically involved in coordination, oversight, and collaboration with awardees to help meet shared goals across the TEDDY consortium.
Which NIH institute is associated with this opportunity?
The opportunity is issued by the National Institutes of Health (NIH). The provided information does not specify a particular NIH institute beyond the NIH context.
What are the CFDA numbers associated with this funding opportunity?
The opportunity is associated with CFDA numbers 93.847 and 93.855.
What activity categories are associated with this FOA?
The FOA falls under health-related activity categories, including food and nutrition and health.
What is the award ceiling listed for this opportunity?
The listing provides an award ceiling of $1,100,000.
How many awards are expected?
The source text shows "ExpectedAwards:" without a number. However, the stated intent is to fund continuation work at the existing six TEDDY Clinical Centers rather than expand the network.
What was the original closing date for applications?
The original closing date listed is April 26, 2018.
What is ultimately being protected or preserved by funding this continuation?
The opportunity is designed to protect the scientific integrity and long-term value of the TEDDY cohort by ensuring participating sites can keep following subjects and gathering the clinical and biological evidence needed to evaluate links between environmental exposures, T1D development, and T1D-related autoimmunity.
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